Abstract. Mercury accumulation in lake sediments has been extensively studied with regard to anthropogenic signals, but natural processes controlling mercury accumulation in the past and the influence of environmental and climatic changes are still poorly understood. In this study we present a 17 300 years old record of mercury accumulation in lake sediments in combination with a multi-proxy investigation of climatic and environmental changes in Southernmost Patagonia (53° S). Mercury accumulation in the remote pristine lake has been highly variable (up to a factor of 16), clearly exceeding the anthropogenic forcing of atmospheric mercury fluxes (factor of 3–5). Statistical data evaluation based on Principle Component Analysis reveals that the dominant driver of variations in mercury accumulation along with other organically bound elements (e.g. copper and yttrium) has been leaching of soluble organic complexes from catchment soils. This indicates that changes in precipitation rates and soils leaching are the most important climatic driver for short term variations in mercury in the lake's sediments. In the long term, however, mercury accumulation rates remain relatively constant (29 μg m⁻² yr⁻¹). This reflects that mercury accumulation in the catchment soils through atmospheric deposition and bedrock weathering has been fairly constant, too. As carbon storage in the soils and transport into the lake have increased, Hg/C ratios in the soil OM decreased. Fluxes of Hg into the lake are therefore mainly determined by the amount of OM leached into the lake and its Hg/C ratio.